Researchers from the Institute of Process Engineering (IPE) of the Chinese Academy of Sciences have proposed a new "nano-micro composite" delivery concept for vaccines and developed a single-dose, dry-powder, inhalable vaccine platform. The vaccine made in the laboratory based on the technology is effective in blocking respiratory viral infection and transmission in animal test, showing great promise for combating future emerging and epidemic infectious diseases. This study was published in Nature on Wednesday. 

In recent years, researchers have made significant progress in developing vaccines for infectious respiratory diseases. However, most of these vaccines are administered through intramuscular injection, which primarily induces a humoral immune response and relies on blood antibodies to neutralize the virus. This approach fails to trigger a mucosal immune response and establish a robust immune barrier in the respiratory tract, according to a release from the research group.

The current liquid form of vaccines requires to be stored in strict low-temperature, and the two- or three-dose vaccination schedule also impacts the overall vaccination rate.

In confronting these problems, professor Wei Wei and professor Ma Guanghui from the State Key Laboratory of Biochemical Engineering at IPE, in cross-disciplinary collaboration with professor Wang Hengliang and professor Zhu Li from the State Key Laboratory of Pathogen and Biosecurity, have developed a new vaccine platform.

This platform combines biodegradable microspheres with protein nanoparticles. The surface of these nanoparticles can simultaneously display multiple antigens, thus inducing a broad-spectrum immune response and expanding the range of vaccine protection. The platform also allows for the quick and convenient development of other respiratory virus vaccines due to the flexibility of antigen presentation.

The platform's unique nano-micro composite structure enables an efficient immune response in the lungs by facilitating high-performance delivery. Once antigen-nanoparticles are released, they can be efficiently taken up by antigen-presenting cells. 

Moreover, this dry powder vaccine significantly reduces storage and transportation costs, making it suitable for areas with limited refrigeration facilities, thus improving immunization rates.

The sustained release of antigens in the vaccine induces long-lasting humoral, cellular, and mucosal immunity with just a single inhalation

In cooperation with professor He Zhanlong of the Institute of Medical Biology of the Chinese Academy of Medical Sciences, the researchers developed a model of airborne protection, close contact protection, and airborne transmission blocking, which demonstrated that an inhaled vaccine is highly effective in preventing the virus infection and transmission.

"The components of this nano-micro system used natural proteins and approved polymer materials, and the effectiveness and safety of the vaccine have been systematically studied in non-human primates, indicating its great potential for clinical translation," professor Wei said.

President Xi Jinping on Monday met with Chief Executive of the Hong Kong Special Administrative Region (HKSAR) John Lee, who is on a duty visit to Beijing.

During the meeting, Xi heard a report from Lee on Hong Kong's current situation and the HKSAR government's work.

The Colorado Supreme Court's unprecedented ruling to declare former US president Donald Trump disqualified from holding the presidency reflects the chaotic judicial system of the US, as well as Democrats' determination to rule the GOP contender out. However, the ruling has limited impact on Trump's support rate, and may even be used as a boost for his election race, experts said on Wednesday. 

The 4-3 ruling came after the court found that Trump allegedly engaged in insurrection with his actions leading up to the storming of the US Capitol on January 6, 2021. The landmark decision marks the first time in history that the US Constitution's insurrection clause - Section 3 of the 14th Amendment - has been used to disqualify a presidential candidate, according to media reports.

Trump's attorneys promised to appeal immediately to the US Supreme Court, which has the final say about constitutional matters. 

Trump's legal spokesperson Alina Habba said the ruling was "attacking the very heart of the nation's democracy," while GOP House Speaker Mike Johnson railed at it as "nothing but a thinly veiled partisan attack."

The ruling by the Colorado court based on the insurrection clause is "chaotic and troublesome," as cases involving the application of the US Constitution are normally under the jurisdiction of federal law and should be decided by federal courts, not state courts like the Colorado Supreme Court, Lü Xiang, a research fellow at the Chinese Academy of Social Sciences, told the Global Times on Wednesday.

Therefore, Trump could appeal to the Supreme Court, arguing that the Colorado court does not have the authority to make such decisions, Lü noted. 

What's more, even if the court has the right to enforce Section 3 of the 14th Amendment, the clause itself is still vague about whether it applies to the presidency, the expert said. 

The issue marks huge splits within the US judicial system, as some believe the presidency should undoubtedly be included in the broad term "officers of the US," while others disagree and say that the state court overstepped its authority, the New York Times reported on US local time Tuesday. 

The case has grabbed significant attention in the US, as it sets the stage for the Supreme Court to examine whether Trump would be eligible to run for another term as president, observers said.

Li Haidong, a professor at the China Foreign Affairs University, holds a different view. "While a significant number of judges in the Supreme Court were nominated by Trump, these judges are loyal to the Constitution, not to Trump," Li said.

Li told the Global Times on Wednesday that a decisive voice will depend on whether the Supreme Court defines the US Capitol incident as an act of rebellion and whether the incident was influenced directly by Trump. However, if the court's rulings are ambiguous, it could mean that Trump can continue to run for office.

US media reports analyzed that Trump does not need Colorado to win next year's presidential election, but the danger lies in the fact that more courts and election officials will follow Colorado's lead and exclude Trump from must-win states.

Lü noted that this dramatic episode reflects the Democrats' determination to bring down Trump, whatever it takes.

While lawsuits challenging Trump's candidacy have been filed in more than 25 states ahead of the 2024 election, the latest national polls show Trump leading Biden as the latter's approval rating hit an all-time low, the British media Independent reported. 

Commenting on whether the decision of the Colorado court has impacted Trump's support rate, experts believe the impact would be quite small, and may even give him an advantage. 

"The matter has room for interpretation in both the legal and political fronts, and Trump is likely to interpret it from a political perspective. This may further reinforce the perception among his supporters that he [Trump] is a victim, creating a sense of sympathy that strengthens their support for him," Li noted. 

Editor's Note:

Caravaggio. Wonders of the Italian Baroque, the final exhibition of the year at Museum of Art Pudong, will open to the public on December 12, 2023. With over 60 authentic works on show, including six iconic masterpieces by Caravaggio and others by over 40 Baroque artists, the exhibition presents a fantastically holistic picture of Baroque art. (Photos: Chen Xia/GT)

"The audience here in Chengdu is incredibly enthusiastic, and I deeply enjoyed the game. Every time we scored or made a good defensive play, the audience gave us big rounds of applause and cheers," basketball player Yu Ai-Che from the Chinese Taipei team told the Global Times on Monday evening after the competition against the Chinese team at the 31st FISU World University Games in Chengdu.

In Monday's Men's basketball competition, the Chinese Taipei team defeated the mainland team with a score of 97:84. Both teams had previously suffered two consecutive defeats by Lithuania and Brazil in the earlier group stage, which meant they had no chance of advancing to the top eight.

"The atmosphere in Chengdu is fantastic, and I'm extremely grateful to the audience. They continually cheered and clapped for our team throughout the game. I've played in the mainland when I was in high school, and I definitely want to play with mainland players again to improve both our techniques," said Yu Ai-Che after the competition.

In addition to the audience's passionate support for both teams from the first period to the last, the Global Times also noted that during the halftime break of the match, the panda-shaped mascot Rongbao and the entire audience sang the song "A Family Who Loves Each Other" together. The Taiwan island's folk song "Maiden of Alisan" resonated with the people present. The two teams also exchanged gifts before the start of the match.

Mainland player Zhang Ning said that he gave plush toys of Rongbao to his friends from the island of Taiwan, just as he would bring back souvenirs for his family.

Chinese golfer Li Linqiang triumphed in the final of the Guotai Cup Men's Professional Match Play on August 26, while Thailand's Dussavi Soopimjit claimed her title in the women's match in Guiyang, Southwest China's Guizhou Province.

The initial lineup for the match consisted of 72 players, 32 men and 40 women. The tournament boasted a total prize fund of 800,000 yuan ($109,692). All professional players who advanced to the formal matches shared the prize money, with 100,000 yuan awarded to the men's champion and 60,000 yuan to the women's champion.

After a fierce competition with Liu Enhua, Li Linqiang clinched the final match over 18 holes, leading by just one hole.

"This is the first match play event I've participated in since turning professional. I felt a rush of excitement today, particularly during the opening holes against Liu. The pressure mounted in the latter stages, but I'm elated to have pulled through," Li remarked after the match.

Zhang Xiaoning, chairman of the China Golf Association, mentioned that this match play event represents an effort by the China Golf Association to create new opportunities for players. "Furthermore, this is the inaugural instance of a professional event being held in Guizhou. Through engagement with the local community, we aim to invigorate the growth of golf in Southwest China."

The Chinese delegation made an impressive start on the first day of the 19th Asian Games in Hangzhou, East China's Zhejiang Province, on Sunday, clinching an astounding 20 gold medals across various sports, including rowing, shooting, wushu and swimming. 

In the rowing events, local Hangzhou girl Zou Jiaqi took the first gold medal of the Hangzhou Asian Games to start a Chinese gold rush at the Fuyang Water Sports Centre. Zou and her doubles partner Qiu Xiuping rowed a strong race in the lightweight women's double sculls final to finish nearly 10 seconds ahead of Uzbekistan, to the delight of the watching crowds both in the grandstands and on the banks of the course.

Qiu said that she was extremely excited when she saw the national flag and heard the national anthem as they rowed past the finish line. 

Zou told media that she wanted to tell her parents she was happy to see they were at the event. 

Speaking of their next goal, the Paris 2024 Olympic Games, the pair did not hide that they are reaching for the top podium. 

"Since we walked off the Hangzhou podium, Paris has become our goal," Qiu said. "We will restart from zero, completing every training session wholeheartedly. We hope to go to the top in Paris."

Later in the morning, Zhang Liang equaled the record of Li Jianxin by winning his fourth Asian Games gold medal in rowing. China won a further four of the five finals on the penultimate day of the rowing regatta. The men's pair was won by Lam San-tung and Wong Wai-chun, also marking China's Team Hong Kong's first gold medal of the ongoing Hangzhou Games.

China's six gold medals take their all-time Asian Games rowing total to 104, including 98 golds. The spectators at the event said that the Chinese rowers demonstrated their impeccable technique and stamina and that their remarkable performance set the tone for the rest of the day.

The Chinese wushu team displayed their agility, strength, and grace, captivating the audience with their breathtaking routines and clinching two gold medals in the men's Changquan final and women's Taijiquan and Taijijian all-round.

Winning the men's Changquan title, 34-year-old veteran Sun Peiyuan achieved his third consecutive Asian Games championships. He told the Global Times that he was excited after winning the title, despite enduring injuries during preparation for the Games. 

"I feel that all the efforts of me and the team, every point of hard work has been rewarded. I have lived up to the expectations of my country and my family," Sun said.

The shooting range also witnessed China's prowess as the country's shooters claimed a gold medal each in the 10 meters air rifle women's team event and 10 meters air rifle women's final. In the 10 meters air rifle women's final, China's 17-year-old Huang Yuting won with a 252.7 ring and set a new Asian Games record.

Powered by world champions such as butterfly queen Zhang Yufei, men's individual medley specialist Wang Shun as well as prodigy Pan Zhanle, the Chinese swim team secured seven gold medals in all seven competitions on the first day.

China's butterfly specialist Zhang eased to victory in the women's 200 meters butterfly with an Asian Games record of 2:05.57. 

Wang, who lit the Asian Games cauldron on Saturday night, was crowned the men's 200 meters individual medley champion after setting a new Asian record of 1:54.62 on Sunday. 

Freestyle prodigy Pan Zhanle smashed the men's 100 meters freestyle Asian record with a sensational 46.97 seconds, becoming the first swimmer in Asia to break the 47-second barrier. 

Distance swimmer Li Bingjie topped the women's 1,500 meters freestyle with a new Asian Games record of 15:51.18, while female breaststroke specialist Tang Qianting claimed the women's 50 meters breaststroke with 29.96 seconds.

Local favorite backstroker Xu Jiayu brought the tally to six as he won the men's 100 meters final with an impressive 52.23 seconds, also a new Asian Games record. 

The night culminated with Chinese female swimming quartet Yang Junxuan, Cheng Yujie, Wu Qingfeng and Zhang Yufei winning the women's 4x100 meters freestyle relay with an Asian Games record of 3:33.96.

Sunday was also the concluding day of the Hangzhou Asian Games's Modern Pentathlon competitions, with the Chinese team collecting gold medals in the women's individual and women's team final.

The Hangzhou Games are scheduled to end on October 8. As the Asian Games continue, all eyes will be on the Chinese delegation as they strive to maintain their dominance and add to their impressive medal tally. The athletes' exceptional performances on the first day have undoubtedly inspired their teammates and instilled a sense of confidence in the entire delegation.

32-year-old Portuguese golfer Ricardo Gouveia won his seventh Challenge Tour tournament at the Hainan Open in South China's Hainan Province on Monday after four days of competition.

He recorded a 272 (-16) to clinch the victory in four rounds, standing out from 120 players from home and abroad. Gouveia carded four rounds under par with a 67 in his first and final rounds, a 68 in the second round, and a 70 in the third round. He recorded 20 birdies in the tournament, highlighted by six in the final round on Monday.

"What an amazing day today. It was one of the toughest rounds of the year, and I played really well on the back nine. I just stayed patient throughout the day. I knew the last few holes were playing into the wind and really tough, so I'm excited to get the win," he said during an interview.

Switzerland's Joel Girrbach finished in second place on 13 under par, while Chinese player Ding Wenyi, Italian Francesco Laporta, and Englishmen Steven Brown and Will Enefer finished a shot further back in third.

Zhang Xiaoning, Chairman of the China Golf Association, said that he is "looking forward to the return of the Hainan Open." The total prize money of this event has been upgraded to half a million dollars. It is the first highest-level international men's professional event held in China after the pandemic, which reflects the determination of the China Golf Association to further promote the development of golf.

Including a more than 2,000-year-old water diversion dam in East China's Anhui Province, four ancient Chinese irrigation works were recently listed as World Heritage Irrigation Structures (WHIS). 

The four Chinese heritage sites are Qimenyan, also known as the "seven-door weir" in Anhui Province; the ­Hongze Lake Irrigation System built in AD199 in East China's Jiangsu Province; Huoquan, a spring type water system in North China's Shanxi Province; and the Baini Weirs, two dams in Central China's Hubei Province. 

Although these projects are generally defined as "irrigation systems," their typologies, geographical conditions and historical value vary. Taking Qimenyan as an example, it is located in a hilly wetland environment and its main channel connected with sub-mechanisms like ponds, ditches and canals. Thus, the system could be used to store as well as distribute water.  

Another iconic project, the Baini Weirs, consists of two 1,000-year-old dams that are still being used for flood control and water supply. It is a typical example of a large-scale stone-built structure in ancient China. 

Yuan Han, an architectural and urban planning expert, told the Global Times that the scattered locations of these sites reveal that "water management" was a "national-level plan" in ancient China. The Chinese ingenuity in irrigation engineering equated with today's concept of "sustainability" as it respected natural conditions. 

"Yin Di Zhi Yi [lit: creating something in line with local conditions] is a major philosophy used in ancient design. It is early advice to the world from China on how to carry out sustainable development," Yuan told the Global Times. 

Including the newly added sites, China has a total of 34 irrigation projects on the WHIS list. The 2023 list was announced at the 74th International Executive Council Meeting of the International Commission on Irrigation and Drainage (ICID) in India. 

A total of 15 projects from countries like India, Iraq and Turkey were all added to the 2023 list. Among them, China's landscape of irrigation systems are the richest and have the widest distribution.  

Environmental expert Jia Boyang told the Global Times that a site should have "several boxes ticked" to be considered a "heritage" site. The evaluation is not limited to looking at a site's history or characteristics.  

"A heritage site should be able to show continued value to humanity and social and cultural developments. These ancient irrigation systems across the country also reflect China's long-standing strength in agriculture," said Jia. 

China's "water project" heritage is an open door for many to look into the country's agricultural history. Ancient irrigation supported not only the harvest on farms, but also the entire country's economic development and cultural exchanges. 

Besides the new batch of function-oriented sites, the Beijing-Hangzhou Grand Canal that was built during the Spring and Autumn Period (770BC-476BC) carries great social importance. Starting from Hangzhou to Beijing, the grand water belt is a major part of China's South-to-North Water Transfer Project. It has promoted the country's overall economic growth while allowing folk and cultural traditions to be exchanged between the northern and southern parts of China. 

Founded in 1950, the ICID is an international platform dedicates to the innovative sustainability of irrigation system design and flood control around the world. 

As a member of the organization, with its burgeoning technological and manufacturing powers, China has co-launched several irrigation projects overseas with countries like Egypt and Kazakhstan.   

"Chinese water engineering projects reflect the country's creative character and also the continuity of the country's profound civilization," said Yuan.